Guangzhou South Railway Station is not recommended to go to Shamian by bus, but you can take the public transport —— Metro.
Follow the signs at Guangzhou South Railway Station, find the subway entrance of Guangzhou South Railway Station, take Line 2 to Haizhu Square Station, transfer to Line 6 to Huangsha Station, get off at Exit F. Then walk across the footbridge, and you can get to the Shamian European amorous feelings area.