It is more convenient to take the Guangzhou-Shenzhen Expressway from Shenzhen to Guangzhou. You can go directly to the Guangzhou-Shenzhen Expressway in Luohu District, Futian District, Nanshan District and Baoan District of Shenzhen. You can also take the Meiguan Expressway to the Guanshen Expressway in Longhua Street, Guanlan Street, Bantian Street and Meilin Street of Futian District of Shenzhen, and then go to the Huanghuang intersection of Zhongtang Town in Dongguan and get on guangyuan expressway to Guangzhou (the Guanshen Expressway will soon be connected with guangyuan expressway).